Salmon DNA
A biological skin treatment in which the PDRN molecule activates adenosine receptors to support collagen synthesis and tissue repair.

Salmon DNA treatment is an injection method that takes advantage of the high biocompatibility of PDRN (polydeoxyribonucleotide) — DNA fragments derived from salmon — with human skin. PDRN's activation of adenosine A2a receptors is reported to have beneficial effects on tissue repair, collagen synthesis and reduction of inflammation. Clinical studies have demonstrated measurable changes in skin texture and elasticity following regular application.
How It's Applied
- Before treatment, a skin evaluation is performed to plan the injection areas and number of sessions.
- The PDRN-containing preparation is injected into the dermal layer of the skin using fine needles.
- A session takes 30–45 minutes; temporary redness and mild swelling after treatment subsides within 24–48 hours.
- Collagen-level effects typically begin to appear after 4–8 weeks of regular treatment.
- Typically 3–4 sessions are planned 2–4 weeks apart, after which maintenance sessions may be recommended.
Who It's For
- May be considered by adults who notice dryness, fine lines or changes in overall skin quality.
- Can be an option for those looking for a biologically-sourced, tissue-friendly ingredient who are open to injection-based care.
- Suitability is determined by physician evaluation, particularly for those with fish allergy, or who are pregnant or breastfeeding.
Frequently Asked Questions
- What is Salmon DNA (PDRN)?
- It is a biological injectable containing PDRN (polydeoxyribonucleotide) derived from salmon; it is evaluated in medicine for its potential to support tissue repair processes.
- What does Salmon DNA do for the skin?
- It aims to support skin hydration, elasticity and overall appearance. It is favored for its potential to stimulate tissue regeneration pathways.
- What is the difference between Salmon DNA and PRP?
- PRP is derived from the patient's own blood, while Salmon DNA is an exogenous substance. Both support tissue renewal through different mechanisms; the physician can advise on the most suitable option.
